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KMID : 0861020100250010033
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Korea Journal of Herbology
2010 Volume.25 No. 1 p.33 ~ p.38
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Effects of NR on Production Levels of Cytokines and Distribution of BAL Cells in Allergic Asthma
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Bae Jin-Hyun
Yoo Ji-Hyun
Kil Ki-Jung
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Abstract
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Objectives: This study was designed to investigate therapeutic effects fo NR on allergic asthma in terms of mesurement of cytokine profiles, distribution of BAL and expression levels of asthma induced by OVA.
Methods: C57BL/6 mouse was divided into normal, NRⅠ, control, and NRⅡ, and Notopterygii Rhizoma Extract was orally administered to the C57BL/6 mice in the normal group and the normal mouse in NRⅠgroup while it was orally administered to the control group after inducing asthma by OVA and NRⅡ. The study measured them by means of ELISA after dividing BALF of each group, and analyzed RT-PCR by using lung tissues.
Results: In our results, lung weight and the number of total cells in the lung and of Leukocyte and Eosinophils in BALF were significantly decreased. In addition, IL-4, IL-5, IL-13, and IgE in BALF were significantly decreased compared to the control group.
Conclusions: These results demonstrate that NR Extract be a desirable altemative therapy for allergic asthma by inhibiting the expressin of immune cells, the activation of inflammatory mediator.
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KEYWORD
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Notopterygii Rhizoma, BALF, asthma, immune cell, herbal medicine
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